Work

Lymphopenia for Age Persistent More Than 2 Weeks in Children Aged Between 1 Month and 5 Years Can Be a Poor Man’s Screening Tool for Combined Immunodeficiency

Year: 2026

Type: article

Abstract: Suspecting combined immunodeficiency disorders (CID) in children with acute infections is the first step in diagnosing this group of disorders. Lymphopenia is one screening investigation for these disorders but it lacks specificity as it is often observed in acute infections. We observed in our study that persistent lymphopenia for age by 2 weeks after illness onset enhances its specificity. Subjecting these children with persistent lymphopenia by 2 weeks to other expensive diagnostic investigations can be a strategy to diagnose CID in resource-limited settings.

Source: Indian journal of clinical medicine

DOI: 10.1177/26339447261433278

Authors: Vijay Arumugam, Christina Mary, Jaikumar Govindaswamy Ramamoorthy

Institution: Jawaharlal Institute of Post Graduate Medical Education and Research

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400