Hereditary gynecological cancer management in women with Lynch syndrome: a survey across Europe
Year: 2026
Type: article
Study design: Observational Study
Abstract: We aim to compare clinical practices in the gynecological management of women with Lynch syndrome across Europe and assess the need for multidisciplinary gynecological care for this high-risk population. European gynecologists involved in the clinical care of women with Lynch syndrome were invited to complete a cross-sectional survey regarding their clinical practices and organization of care. All participating gynecologists were based in hospitals that are members of the European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS). A total of 33 gynecologists (57%) from 25 unique hospitals across 12 countries participated in the survey. National guidelines on the gynecological management of women with Lynch syndrome were absent in a significant number of European countries. Local multidisciplinary team meetings were available in 61% of hospitals. Considerable heterogeneity was reported in the organization of care, as well as in surveillance, prevention, and treatment strategies. Standardized European guidelines for the gynecological care of women with Lynch syndrome are warranted to promote uniformity. Gynecologists specialized in hereditary cancer should take the lead in developing and implementing these guidelines. Hospitals managing women with Lynch syndrome should have the resources to organize multidisciplinary team meetings, which are crucial for the effective implementation of these guidelines and the improvement of personalized care.
Source: Familial Cancer
Authors: Kevin J. J. Kwinten, Joanne A. de Hullu, ERN GENTURIS Survey Group, Helen Bolton, Monique M. A. Brood-van Zanten, Valentina Chiappa, Stefan Cosyns, Sergi Fernandez-Gonzalez, Angelique Flöter Rådestad, Sophie Frank, Rieke Gellner, Susanna Housmans, Nina Kovacevic, Iveta Mikeltadze, Sebastjan Merlo, Charlotte Møller, Johanna M. A. Pijnenborg, Kresten R. Petersen, Anna Myriam Perrone, Neil A. J. Ryan, Claire Saule, Rawand Salihi, Montserrat Serra Landete, H Lena C van Doorn, Errico Zupi, Lena Steinkasserer, Nicoline Hoogerbrugge, Anne M. van Altena
Institutions: Radboud University Nijmegen, Radboud University Medical Center, Cambridge University Hospitals NHS Foundation Trust, The Netherlands Cancer Institute, Fondazione IRCCS Istituto Nazionale dei Tumori, Universitair Ziekenhuis Brussel, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Universitat de Barcelona, Karolinska Institutet, Institut Curie, Medizinische Hochschule Hannover, KU Leuven, Institute of Oncology Ljubljana, Tartu University Hospital, Aarhus University Hospital, University of Copenhagen, Herlev Hospital, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna, University of Edinburgh, Ghent University Hospital, Universitat Autònoma de Barcelona, Hospital Universitari Germans Trias i Pujol
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,990
OpenAlex ID: W7144146472