浸潤性膀胱癌およびリンパ節転移を有する膀胱癌に対するm-vac療法の治療成績
Year: 1989
Type: article
Abstract: Sixteen patients with lymph nodes metastases and/or locally advanced bladder carcinoma were treated with a combination chemotherapy regimen consisting of methotrexate, vinblastine, adriamycin, and cisplatin (M-VAC) from November 1986 through September 1988. There were 14 men and 2 women. The median age was 61.9 years, with a range from 43 to 81 years. Complete response (CR) was observed in 6 of 16 patients (38%), partial response (PR) was confirmed in 5 of 16 patients (31%), and overall response rate was 69%. Median duration of response was 10.3 and 5.2 months in CR and PR patients, respectively. The myelosuppression with this regimen was tolerable. This study demonstrates that the M-VAC regimen is effective in the invasive bladder carcinoma with or without lymph nodes metastases. However, the duration of response is relatively short, and the true long-term benefits of this regimen remain to be determined.
Authors: Igawa, Mikio, Ueki, Tetsuhiro, Ueda, Mitsutaka, Okada, Katsuhiko, Usui, Tsuguru, Ohnishi, Yoshio, Kume, Takashi, Masu, Chikao, Ishino, Toshikatsu, Nakatsu, Hiroshi, Kodama, Mitsuto, Kitano, Taiji, Ukai, Rinzo, Fujii, Motohiro, Hiromoto, Nobuyuki, Nakano, Hiroshi, Tado, Osamu, Hatachi, Kousuke, Matsuki, Satoru, Ono, Hiroshi, Hirayama, Masaaki, Fukushige, Mitsuru, Shiraishi, Tsuneo
Institutions: Hiroshima University, Shobara Red Cross Hospital, Suiseikai Kajikawa Hospital, Chugoku Rosai Hospital, Shimane Prefectural Central Hospital, Onomichi General Hospital, West Japan Railway Company (Japan), Hiroshima General Hospital, Kitakyushu General Hospital, Hiroshima City Asa Citizens Hospital, Kure Medical Center, Hiroshima Prefectural Hospital, Matsuyama Red Cross Hospital
Language: Japanese
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7144454073