Type: conference-paper
Abstract: Recent evidence suggests the involvement of corticotropin-releasing factor (CRF) in reward system.Here, we evaluated whether CRF modulates the reinstatement of methamphetamine (METH)-seeking behavior induced by stress using a drug-self administration paradigm in rats.Rats were trained to lever-press for intravenous METH accompanied by light and tone (drug-associated cues) and then underwent extinction training (saline substituted for METH without cues).Under the extinction condition, the inhibitory effects of a CRF receptor antagonist on the reinstatement of METH-seeking behavior were assessed.The non-selective CRF receptor antagonist -helical CRF9-41 attenuated METH-seeking behavior induced by drug associated-cues, METH-priming or stress.CRF levels both in the amygdala and in plasma were significantly increased on day 10 of withdrawal after METH self-administration.The increased CRF levels in the amygdala may, at least in part, contribute to the reinstatement of METH-seeking behavior.
Author: NAWATA, Yoko
Language: Japanese
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7144492445