Year: 2022
Type: dissertation
Study design: Observational Study
Abstract: In this study, the serum metabolic profiles of 10 female patients with restricting type anorexia nervosa (ANR) were compared to those of 10 age-matched healthy female controls.While the levels of amino acids were lower among the patients than among the controls, the levels of uremic toxins, including p-cresyl sulfate (PCS), indole-3-acetic acid, and phenyl sulfate, were higher in ANR patients.The serum PCS levels correlated positively with the abundance of the Clostridium coccoides group or the C. leptum subgroup in the feces of patients, but not in those of controls.Collectively, these results indicate that the serum metabolic profiles of patients with ANR differ from those of healthy women in terms of both decreased amino acid levels and increased uremic toxins.Gut microbes including C. coccoides or C. leptum may be involved in such an increase in uremic toxins.
Author: MIYATA, Noriyuki
Institution: Kyushu University
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Awards: Elucidating the Pathophysiology of Anorexia Nervosa through the Microbiota-Gut-Brain Axis: Development of Novel Nutritional Therapies, Elucidation of pathophysiology of anorexia nervosa and creation of new paradigm: Control of body weight and behavioral characteristics by intestinal bacteria, Stress causes bacterial translocation: Analysis by high sensitive measurement method, G8602394483
OpenAlex ID: W7144609659