Year: 2017
Type: dissertation
Abstract: Cell migration potency is often regulated by extracellular stimuli. We previously reported that the migration potency of the oral squamous cell carcinoma (OSCC) cell lines SAS and HSC3 have high epidermal growth factor receptor (EGFR) inhibitor sensitivity, while the migration of HSC4 is not affected. Hepatocyte growth factor (HGF)/c-Met is known as one of the signaling pathways for cell migration in some cancer cells. In this study, we demonstrated the importance of the c-Met signaling pathway for filopodia and lamellipodia formation in cell migration using HSC4. The cell migration of HSC4 used the HGF/c-Met pathway. Additionally, the EGF/EGFR pathway is not related to lamellipodia formation. The HGF/c-Met pathway is important for the formation of filopodia and lamellipodia in HSC4. Furthermore, signaling from c-Met increases the amount of lamellipodin protein, which is necessary for formation of lamellipodia. Our results suggested that signaling from the HGF/c-Met pathway increases the quantity of lamellipodin protein, and induces cell migratory capacity by inducing lamellipodia forming potency in HSC4.
Author: 安井, 大樹
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7144615430