直鎖状ユビキチン鎖生成を介した炎症・免疫シグナル制御と疾患
Year: 2016
Type: article
Abstract: Ubiquitination is a post-translational modification involved in the regulation of a wide variety of cellular functions, such as proteasomal protein degradation, membrane trafficking, DNA repair, and signal transduction pathways, such as nuclear factor-κB (NF-κB) pathway. NF-κB is crucial for inflammatory and immune responses, and aberrant NF-κB signaling is implicated in multiple disorders. We identified that LUBAC (linear ubiquitin chain assembly complex), composed of HOIL-1L, HOIP, and SHARPIN, generates a novel type of Met1(M1)-linked linear polyubiquitin chain, and specifically regulates the canonical NF-κB pathway. Moreover, we revealed that a linear ubiquitin-binding protein, optineurin (OPTN), contributes to suppression of NF-κB and apoptotic pathway, and the aberrant functions in linear ubiquitin-binding of OPTN closely associates with amyotrophic lateral sclerosis (ALS).
Author: Tokunaga, Fuminori
Institution: Osaka City University
Language: Japanese
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7144874951