Year: 2018
Type: dissertation
Abstract: Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the extent to which these events contribute to the Aβ pathologies remains unclear. We performed inter-species comparative gene expression profiling between AD patient brains and the App^<NL-G-F/NL-G-F> and 3xTg-AD-H mouse models. Genes commonly altered in App^<NL-G-F/NL-G-F> and human AD cortices correlated with the inflammatory response or immunological disease. Among them, expression of AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increased in the App^<NL-G-F/NL-G-F> cortex as Aβ amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the 3xTg-AD-H and human AD cortices correlated with neurological disease. The App^<NL-G-F/NL-G-F> cortex also had altered expression of genes (Abi3, Apoe, Bin2, Cd33, Ctsc, Dock2, Fcer1g, Frmd6, Hck, Inpp5D, Ly86, Plcg2, Trem2, Tyrobp) defined as risk factors for AD by genome-wide association study or identified as genetic nodes in late-onset AD. These results suggest a strong correlation between cortical Aβ amyloidosis and the neuroinflammatory response and provide a better understanding of the involvement of gender effects in the development of AD.
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress, G6230918249, Implication of oxidative damage in nucleic acids and its defense mechanisms for development of brain dysfunction which may be caused by chronic kidney disease, Investigation of brain damage caused by reactive oxygen species and its defense mechanisms
OpenAlex ID: W7145163347