Year: 2025
Type: dissertation
Abstract: Environmental factors such as ultraviolet radiation, air pollutants, and temperature differences affect our skin, causing skin problems.One of the effects of these environmental factors is reported to be the increase of reactive oxygen species (ROS), which causes various skin problems such as excessive melanin production and skin aging.Skin brightness is one of the landmarks for skin condition.Excessive ROS derived from environmental factors promotes melanin production.In addition, skin turnover, which is the regular process of skin replacement, is delayed due to the excessive ROS, preventing the removal of old and dark skin and renewal of new skin cells.Skin damage and increased melanin production are caused not only by ROS through external factors from the environment, but also by internal factors from liver.The liver has many functions such as detoxification and metabolism.Liver is also constantly exposed to ROS through liver activities such as metabolism.Imbalance in ROS levels causes liver dysfunction.Once liver dysfunction occurs, toxic or inflammation-related substances from liver reach into the skin, causing damage and the induction of melanogenesis.Therefore, maintaining liver function from excessive ROS is important for healthy skin.Moreover, some people desire to whiten their complexion, and achieving that goal positively affects their quality of life (QOL).In view of the above, reducing skin damage from external and internal factors are essential, and maintaining a favorable skin environment is an important effort toward the promotion of skin health and improving people's QOL.Glutathione (GSH) is a tripeptide consisting of glutamic acid, cysteine, and glycine.GSH is one of the most abundant antioxidants in humans.Several biological functions of GSH includes skin protection and liver detoxification.Therefore, this study QOL.
Authors: 打田 慶明, ウチダ ヨシアキ, UCHIDA YOSHIAKI
Language: Japanese
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7145972470