インターロイキン-15による生体防御調節機構
Year: 2004
Type: article
Abstract: Although some functional activities of interleukin (IL) -15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2/IL-15 system demonstrate distinct roles of IL-15 for the activation of innate as well as acquired immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRyu+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15/IL-15R system.
Author: OHTEKI, Toshiaki
Language: Japanese
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7145999831