Year: 1963
Type: article
Study design: Observational Study
Abstract: Recent data have suggested abnormalities of many thyroid function tests in nephrotic syndrome. The thyroid status in 18 patients with nephrotic syndrome was studied on the following subjects ; i) usual thyroid function tests, ii) thyroxine metabolism, iii) thyroxine binding capacity of serum proteins by means of continuous flow electrophpolesis, and iv) thyroidal-^<131>I uptake-TsH test. Conclusions ; 1) Urinary excretion of FBI, dilated thyroxine space and decreased thyroxine binding capacity of TBG and TBPA result in low serum FBI and short biological half time of ^<131>I-thyroxine. 2) High ^<131>I-triiodothyronine erythrocyte uptake is due to deccreased thyroxine binding capacity of serum proteins. 3) Peripheral matabolic disturbance of thyroxine in nephrotic syndrome probably increases TSH secretion in the pipuitary gland, which will result in high thyroidal ^<131>I-uptake. 4) Pipuitary-thyroid axis disturburnce is thought to exist in nephrotic syndrome. 5) Most of the abnormalities in thyroid function tests will correlate with the severity of the disease in their degrees.
Author: 福本,泰彦
Language: Japanese
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7146327408