Work

From Risk to Action: Predictive Profiling and Contemporary Treatment Context in Rheumatoid Arthritis Mortality

Year: 2026

Type: article

Abstract: We were intrigued by the recent article by Joerns et al1 that drew 4 decades of data from the Rochester Epidemiology Project (REP) to demonstrate a more than 2-fold increase in respiratory-related mortality among seropositive patients with rheumatoid arthritis (RA) compared with non-RA controls—a risk not observed in seronegative RA. This finding solidifies serostatus as a critical prognostic marker. To help translate this epidemiological insight into clinical practice, we wish to propose 3 methodological and interpretive refinements.

Source: The Journal of Rheumatology

DOI: 10.3899/jrheum.2025-1119

Authors: Zhen Wang, Jiasi Zheng, Wu-Kai Ma

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health

Award: Temporal associations between systemic inflammation, cardiovascular risk profile and development of Alzheimer’s disease and related dementias in patients with rheumatoid arthritis