Figure S7 from In Vivo Auto-tuning of Antibody–Drug Conjugate Delivery to Maximize Efficacy Using High-Avidity, Low-Affinity Antibodies
Year: 2026
Type: other
Abstract: Pharmacodynamic Staining of T-Dxd with and without HALA Carrier Dose. Images of high HER2 expression NCI-N87 tumors with 6.4 mg/kg of T-Dxd (top) or 6.4 mg/kg of T-Dxd +32 mg/kg S12 carrier dose (5:1 ratio, bottom). The pharmacodynamic signal from γH2AX (red) in sections of tumor distal from ADC staining (green) indicate the bystander effect of T-DXd. However, some regions containing tumor cells had low levels of DNA damage (top). The staining intensity is lower but more uniform with the addition of the S12 HALA antibody (bottom).
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7147035462
Cites:
Cited by:
Related to: