Supplementary Figure S7 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants
Year: 2026
Type: supplementary-materials
Abstract: Supplementary Figure S7 shows the dose- and time-dependent inhibition of DUSP6 and pERK in KRAS-mutant CDX models treated with BBO-11818, as well as the mean body weight in a KRASG12D CDX model treated with BBO-11818.
Authors: Carlos Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh, Nadege Gitego, Zuhui Zhang, Albert H. Chan, Alok K. Sharma, Patrick A. Alexander, Jin Shu, Yue Yang, Megan Rigby, Roger Ma, Saman Setoodeh, Brian P. Smith, Jun Pei, Dana Rabara, Erik K. Larsen, David M. Turner, Cathy Zhang, Cindy Feng, Siyu Feng, James P. Stice, Rui Xu, Ken Lin, Andrew G. Stephen, Felice C. Lightstone, Chunmei Ji, Keshi Wang, Dhirendra K. Simanshu, Dwight V. Nissley, Eli Wallace, Bin Wang, Kerstin W. Sinkevicius, Frank McCormick, Pedro J. Beltran
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7147046669