Short-term modulation of epileptic network with low-frequency thalamic stimulation
Year: 2026
Type: article
Abstract: Thalamic neuromodulation is an established treatment option for drug-resistant epilepsy (DRE), yet how thalamic input reshapes cortico-cortical interactions on the sub-second timescale remains poorly defined.1 Deep brain stimulation (DBS) of the anterior thalamic nucleus (AN) reduces seizures with benefit in focal DRE,1 and for multifocal or generalized phenotypes, DBS and brain-responsive neurostimulation (RNS) targeting the centromedian nucleus (CM) likewise demonstrate seizure reduction.2,3 DBS typically uses continuous high-frequency stimulation; still, single-pulse electrical stimulation (SPES) during stereo-EEG (SEEG) provides a complementary perturbational assay to quantify immediate thalamic network engagement and derive pulse-locked biomarkers for subsequent testing under therapeutic stimulation paradigms.
Source: Brain stimulation
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,430
Awards: In Vivo Studies of the Epileptic Hippocampus, G5590979896, Defining the Epileptogenic Network and Identifying which Components Generate Seizures, Translational Platform for Epilepsy Therapy and Biomarker Discovery, Refining neurophysiological biomarkers of epilepsy using deep learning to guide pediatric epilepsy surgery
OpenAlex ID: W7147047775