Ozone Therapy Modulates Histopathological and Biochemical Markers in Mice with Induced Polycystic Ovary Syndrome
Year: 2026
Type: article
Abstract: Background — Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by polycystic ovaries and associated oxidative stress. This study assessed the potential beneficial effects of ozone therapy on ovarian tissue in mice with induced PCOS. Methods — Forty-two female mice were distributed between six groups: a control group, a PCOS group, a PCOS group treated with ozone (45, 60, and 70 μg/mL), and a PCOS group treated with clomiphene citrate (1.5 mg/kg). PCOS was induced by injection of estradiol valerate (EV), and treatment was administered for four weeks. Data were analyzed using SPSS software, with a significance level of p
Source: Russian Open Medical Journal
Authors: Reza Dadfar, Maryam Ghorbani, Morteza Izadi, Hadi Ghaleh, Mojtaba Sepandi, Hosein Bahadoran, Javad Sarshoori
Institution: Baqiyatallah University of Medical Sciences
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7147066376
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