Work

Collagen depletion, not keloid formation, defines lobomycosis lesions: a paired skin analysis

Year: 2026

Type: article

Abstract: . Lesions are often described as keloid-like, but the organization of the dermal extracellular matrix remains poorly characterized. We analyzed paired lesional and non-lesional skin from five patients in the Brazilian Amazon using histology and immunohistochemistry. Picrosirius red staining revealed depletion and disorganization of type I collagen in lesional dermis. Immunohistochemistry showed modest differences in biglycan and decorin expression, with spatial redistribution of biglycan near fungal structures. Patients treated with itraconazole showed lesion stabilization. These findings indicate collagen loss rather than true keloid formation.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2026.100787

Authors: Franciely G. Gonçalves, Juliana M. Veridiano, Nuha A. Dsouki, Maria Aparecida S. Pinhal, Gabriel Z. Laporta

Institutions: Universidade Federal do Acre, Faculdade de Medicina do ABC, Universidade Federal do ABC, University of South Carolina

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650