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Theta-gamma phase-amplitude coupling in the dynamic pain connectome in healthy individuals and abnormalities in people with chronic pain

Year: 2026
Type: article
Abstract: The experience of pain arises through the integration of information across brain regions and networks. Theta-gamma phase-amplitude coupling (PAC) reflects interactions between neuronal processes in the brain. We analyzed a previously published dataset to identify PAC of intrinsic brain activity in nociceptive processing/modulation regions and found sex-specific disruptions in people with chronic pain. This study implicates theta-gamma PAC as a means to shape nociception and PAC failures as a possible mechanistic contributor to chronic pain.
DOI: 10.1152/jn.00492.2025
Authors: Ariana Seyed Makki, Kasey Sarah Hemington, Anton Rogachov, Joshua C. Cheng, Rachael L. Bosma, Natalie R. Osborne, Rima El-Sayed, Robert D. Inman, Benjamin Thomas Dunkley, Karen Deborah Davis
Institutions: University Health Network, University of Toronto, University of Nottingham, Hospital for Sick Children, SickKids Foundation, Sickkids Research Institute
Language: English
Open Access status: hybrid
OpenAlex ID: W7147075620
FWCI: 4.272
Cites: 52
Cited by: 1
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