Work

Cyclic alternating pattern in sleep electroencephalography as a novel predictor of dementia: A prospective study

Year: 2026

Type: article

Study design: Observational Study

Abstract: INTRODUCTION: Cyclic alternating pattern (CAP) is a sleep physiological rhythm observed during non-rapid eye movement (NREM) stage. However, the potential role of CAP for risk of dementia remains unknown. METHODS: We studied 2,557 participants enrolled in the prospective Osteoporotic Fractures in Men (MrOS) Sleep Study. CAP features were calculated from electroencephalogram (EEG). The primary outcomes are probable dementia determined by physician diagnosis, Alzheimer's medication use, or a significant cognitive decline. RESULTS: Participants in the lowest tertile of A2 index exhibited an increased risk of dementia compared to those in the highest tertile (hazard ratio [HR] = 2.00, 95% confidence interval [CI]: 1.38-2.90). Further, a lower combined A2+A3 index and shorter CAP sequence duration were associated with a higher risk of dementia. The Shapley Additive Explanations method indicates that CAP features were more predictive of dementia risk than conventional sleep parameters. DISCUSSION: These findings suggest that specific CAP features may serve as useful predictors to identify those older men at risk of dementia.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.71331

Authors: Ying Zheng, Xinyue Wu, Haizhen Chen, Fan Li, Kristine Yaffe, Katie Stone, Yue Leng, Xiao Tan

Institutions: Sir Run Run Shaw Hospital, Zhejiang University, Dalian University of Technology, University of California, San Francisco, California Pacific Medical Center, Karolinska Institutet

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,200

Funders: National Natural Science Foundation of China, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences

Awards: G1101846420, G1206950260, Outcomes of Sleep Disorders in Older Men-Minneapolis, G1549444152, G1787333407, G1817814383, G2082624215, G2160302164, G239771632, G2441403366, G2544295915, G2704506787, G2929263391, G2948719655, G3243374678, G327188308, G3396628412, G3609537244, Development of novel polysomnography-based digital biomarkers to predict Alzheimer’s disease and Parkinson’s disease in real world settings, G373744689, G3990106893, G402576333, G4253755194, G4276072587, G4509871131, G4680823173, G4712859843, G5281952516, G5358148953, G538346131, G5531298794, G555675153, G5797542657, G585648573, Outcomes of Sleep Disorders in Older Men-Portland, G6210582792, G624497702, G6566566152, G659495149, G687823276, G7058527481, G715275891, G7315168720, G7385293372, G7446983892, Outcomes of Sleep Disorders in Older Men, Outcomes of Sleep Disorders in Older Men-Birmingham, G7928184020, G7991420222, G8100392052, Outcomes of Sleep Disorders in Older Men - Pittsburgh, G8511401681, G870119955, G8827260454, G8909198566, G9000005319, G9000012074, G9000032347, G9000033571, G9000050931, G9000062576, G9000066146, G9000085452, G9000088132, G9000102855, G9000111449, G9000130823, G9000153370, G9000160606, G9000195997, G9000239259, G9000283869, G9000288314, G9000295694, G9000305395, G9000324732, G91958607

OpenAlex ID: W7147121335

FWCI: 4.497

Cites: 67

Cited by: 1

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