2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults
Year: 2026
Type: article
Abstract: This article provides a focused update to the clinical practice guideline on the treatment and management of people with COVID-19, developed by the Infectious Diseases Society of America. The guideline panel presents 9 updated recommendations on the use of nirmatrelvir/ritonavir, remdesivir, and molnupiravir, in adults with mild to moderate COVID-19. The recommendations are based on evidence derived from a systematic literature review and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The panel also provides a section on how to apply these recommendations, including an algorithm on the selection of antivirals.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciaf680
Authors: Amy Hirsch Shumaker, Adarsh Bhimraj, Roger Bedimo, Vincent Chi-Chung Cheng, Kara W Chew, Eric S Daar, David V Glidden, Robert W Shafer, Phyllis C Tien, Lindsey R Baden, Kelly Cawcutt, Kathleen Chiotos, Amy L Dzierba, Erica J Hardy, Steven Johnson, Arthur Y Kim, Christine MacBrayne, Greg S Martin, Nandita Nadig, Mari M Nakamura, Carlos R Oliveira, Jeffrey C Pearson, Laura Riley, Shmuel Shoham, Pablo Tebas, Zachary Willis, Joshua Wolf, Jennifer Loveless, Rebecca L Morgan, Yngve Falck-Ytter, Rajesh T Gandhi
Institutions: VA Northeast Ohio Healthcare System, Case Western Reserve University, Houston Methodist, VA North Texas Health Care System, The University of Texas Southwestern Medical Center, Queen Mary Hospital, University of Hong Kong, University of California, Los Angeles, Harbor–UCLA Medical Center, University of California, San Francisco, Stanford University, San Francisco VA Health Care System, Brigham and Women's Hospital, Harvard University, University of Nebraska Medical Center, Children's Hospital of Philadelphia, University of Pennsylvania, New York University, Brown University, University of Colorado Anschutz, University of Colorado Denver, Massachusetts General Hospital, Children's Hospital Colorado, Emory University, Northwestern University, Boston Children's Hospital, Yale University, NewYork–Presbyterian Hospital, Weill Cornell Medicine, Weill Cornell Medical Center, Johns Hopkins University, Johns Hopkins Medicine, University of North Carolina at Chapel Hill, St. Jude Children's Research Hospital, Infectious Diseases Society of America, McMaster University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G1234541941
OpenAlex ID: W7147127129