Work

Prognostic Significance of CRP and CA 15-3 Levels in the Diagnosis of Breast Cancer: A Comparative Study

Year: 2026

Type: article

Abstract: Background — C-reactive protein (CRP) and cancer antigen 15-3 (CA 15-3) are commonly studied biomarkers in breast cancer, but their prognostic significance at diagnosis remains unclear. Aim: Our study aimed to assess the prognostic value of serum CRP and CA 15-3 levels in newly diagnosed breast cancer patients. Methods — We enrolled 39 patients with primary breast cancer in our single-center study. Serum CRP and CA 15-3 levels were measured at diagnosis. Receiver operating characteristic (ROC) analysis was employed to determine optimal cut-off values. Survival outcomes were analyzed. Results — Elevated CRP and CA 15-3 levels were associated with shorter progression-free survival and overall survival. In particular, CRP demonstrated significant prognostic value. However, due to the critically small sample size, the obtained results should be considered preliminary. Conclusion — Serum CRP and CA 15-3 levels may serve as potential prognostic markers in breast cancer. These results are hypothetical and require confirmation in larger cohorts.

Source: Russian Open Medical Journal

DOI: 10.15275/rusomj.2026.0107

Authors: Zein Douba, Rama Ibrahim

Institution: Latakia University

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Tishreen University