Work

Harnessing AlphaFold3 to elucidate BBSome structure and protein partners

Year: 2026

Type: article

Abstract: This study combines AI modeling and experimental validation to define key structural features and receptor interactions of the BBSome complex. The analysis identifies BBS1 and BBS9 as central hubs, reveals how the BBS1 M390R mutation destabilizes the complex, and uncovers novel contacts with various receptors including those involved in metabolic regulation. These findings provide a predictive framework linking BBSome structure to ciliary signaling and metabolic regulation in Bardet–Biedl syndrome.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00804.2025

Authors: Deng Fu Guo, Younes Rouabhi, Mallory Tollefson, Kai Vorhies, Kamal Rahmouni

Institutions: University of Iowa, Iowa City VA Health Care System

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Institutes of Health

Awards: G1405078454, G8272229792, G9000036710, Neuronal Cilia in Hypertension, Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated Hypertension