Year: 2026
Type: article
Abstract: Epoxy alcohols derived from 2-benzylidene-1-indanones undergo rearrangement to 2-naphthols when exposed to trifluoroacetic acid. The reaction sequence tolerates a variety of functional groups from both the parent indanone and the benzaldehyde derivatives. No chromatographic purification is required until the final synthetic step, and the epoxy alcohol syntheses use only water and alcohols as solvents. The synthesis is operationally simple, and the 2-naphthol products can be easily derivatized into pharmaceutically relevant compounds.
Source: The Journal of Organic Chemistry
Authors: Jack B. Story, Kalista E. Ringler, Chi L. Nguyen, Myles J. Drance, Evan M. Howard
Institution: Vassar College
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7147205669