Work

The impact of microsphere deposition algorithm complexity on microdosimetry following Yttrium-90 radioembolization

Year: 2026

Type: article

Abstract: The microsphere spatial distribution following Yttrium-90 radioembolization ( 90 Y-RE) is inherently nonuniform, resulting in substantial microscopic dose heterogeneity not captured by conventional macroscopic dosimetry models. The motivation for this study was to build a robust framework to further understand the relationship between microdosimetry and macrodosimetry-based clinical outcomes. In this study, a stochastic microsphere deposition algorithm sampled histologically-derived cumulative distribution functions (CDFs) governing microsphere cluster diameter ( C dia ), distance between clusters ( C dist ), and cluster population ( C pop ). Six unique models were generated to examine the impact of algorithm complexity on the corresponding absorbed dose distribution, ranging from a completely uniform to fully stochastic reference model. A two-sample statistical Kolmogorov-Smirnov test compared C dia , C dist , and C pop derived separately from discrete and continuous CDFs. Microdosimetry calculations were performed by convolving a high-resolution dose-voxel kernel with each model. The mean absorbed dose D mean and various dose-volume metrics ( D x , x = 1 , 5 , 10 , 50 , 90 , 95 , 99 ) were calculated and compared to the reference model to assess the impact of algorithm complexity on dose metric error ( E x ). Published median values of C dia , C dist , and

Source: Biomedical Physics & Engineering Express

DOI: 10.1088/2057-1976/ae5972

Authors: E Courtney Henry, Benjamin P Lopez, S Cheenu Kappadath

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,400