Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study
Year: 2026
Type: article
Abstract: In this international, multicenter prospective study, implementing penicillin direct oral challenge (DOC) using a digital toolkit was acceptable, feasible, and sustainable. Audit and feedback increased activity, particularly among pharmacists. Safety was maintained across heterogeneous DOC protocols, validating a pragmatic, scalable approach that supports local adaptation.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciag083
Authors: Elise A Mitri, Sara Vogrin, Camille Paynter, Luke R Fletcher, Jonny Peter, Neil Powell, Sara Barnes, Philip H Li, Ana Maria Copaescu, Nicholas A Turner, Fiona James, Richard Sullivan, Maryam Sherkat Masoum, Matthew Rawlins, Geoff Mackay, Benjamin J Smith, Patricia Kilfoyle, Daniel Forster, Morgan Rose, Raquel Cowan, Kylie Alcorn, Anna Brischetto, Andrew Mahony, Andrew Redmond, Arindam Chakravorty, Zaal Meher-Homji, Chino Yuson, Simeon Crawford, Greg Weeks, Sasheela Sri La Sri Ponnampalavanar, Constance Katelaris, Priscilla Tran, Jennifer O’Hern, Jack Godsell, Trisha N Peel, Indy Sandaradura, David New, Candice Holland, Tim Cutfield, Sarah Coghill, Caitlin Hand, Jacob Williams, Jaclyn Bishop, Belinda Lambros, Cascia Day, Courtney Ierano, Natasha E Holmes, Jason A Roberts, Suran L Fernando, Marlena Klaic, Jason A Trubiano, for the International Network of Antibiotic Allergy Nations (iNAAN) study group, Kyra Chua, Joseph De Luca, Gemma Reynolds, Evelyn Andrews, Daniel Lapirow, Abby Douglas, Tanya Crichton, Kate Guy, Jessica Jarvis, Tapiwa Rusike, Benjamin Bowen, Martin Keen, Suman Adhikari, Sara Nobrega, Ekua Brenu, Rachael Roberts, Lilian Whelan, Romeo Torres, Chloe Edwards, Laura Bywater, Jamma Li, Therese Boyle, Melanie Figtree, Jessica Bui, Christy El-Khoury, Claire Italiano, Elizabeth Leahy, Emily Heke, Antje Lutjen, Kevin Nguyen, Marsus Pumar, Mittal Patel, Madonna Khreish, Nazanin Khorshidi, Amanda Nichols, Maria Deetlefs, Marshe Maharaj, Cathryn McDougall, Jason Fok, Frank Thien, Stephen Guy, Kylie D’Arcy-Evans, John Dyer, Melinda Jiang, Saima Ahmad, Janice Chiang, Alicia Neels, Callum Maggs, Caroline Bartolo, Nicholas Ah Yui, Karen Lim, Kathryn Wilks, Sarah Kingscote, Lisa Course, Kate Morton, Michelle Donohue, Jack Cross, Samuel Smith, Philip Tibbits, Jenny Park, Gabrielle Chau, Lawrence Ong, Sanjay Swaminathan, Sarah Keady, Lakshana Kalatharan, Raelene Vine, Judy Lamb, Jenny Wan Sai Cheong, David Brownridge, David Kong, Michael Loftus, Jodi Poole, Leeanne Atkinson, Amrita Ronnachit, Frederick Lee, Peter Bradhurst, Alex Stoyanov, Nicholas Urriola, Lisa Horgan, Karen Wells, Kristine Millar, Sophie Briggs, Chloe Bishop, Joseph Doyle, Rachael Leng, Esha Tamrakar, Kelly Cairns, Ng Rong Xiang, Anjanna Kukreja, Sheron Goh Sir Loon, Ong Hang Cheng, Bushra Binti Megat Johari, Sazali Basri, Ng Sin Hui, Tan Yee Ann, Ho Ai Wui, Jacky Richards, Daniel Hearsey, Nicola Leigh, Elizabeth Haigh, Marie Thomas, Helen Winn, Tamsyn Lewis, Angie Gray, Jane Williams, Sophie Weeks, Amanda Pritchard, Owen O’Reilly, Nathan Ratnam, Shamika Ratnayake, Hoan Dang, Sarah Risdale, Kim Ta, Alice Young, Jacqueline can der Meulen, Rocky Shi, Jane Wong, Valerie Chiang, Gordon Chu, James Hooi, Moneerah Algassim, Adhora Mir, Rachael Wiedmann, Rebekah Wrenn, Natalie Harris, Amy Mackowiak, Karen Watt, Sylvia White, Jacob Griffiths, Katie Jodrell, Michaela Lucas, Benjamin Mulo, Astrid Arellano, Christopher Kleeman, Kate Grogan, Steven Tong, Samantha Chan, Kasha Singh, Douglas Johnson, Kymble Spriggs, Samuel Thorburn, Catherine Fitzpatrick, Jessie Zhou, Karen Giang, Christina Vytilingam, Amanda Jackson, Maureen Turner, Javier Haurat, Wisam Abdelaziz
Institutions: The University of Melbourne, Austin Hospital, Peter Doherty Institute, Austin Health, University of Cape Town, Groote Schuur Hospital, Royal Cornwall Hospital Trust, Royal Cornwall Hospital, Monash Health, Monash University, University of Hong Kong, McGill University Health Centre, Duke University, Duke Medical Center, UNSW Sydney, St George Hospital, Royal Perth Hospital, Fiona Stanley Hospital, Albury Wodonga Health, Western Health, The University of Queensland, Sunshine Coast University Hospital, Eastern Health, Peter MacCallum Cancer Centre, Grampians Health, Griffith University, Gold Coast Hospital, Redcliffe Hospital, Bendigo Health, Royal Brisbane and Women's Hospital, Latrobe Regional Hospital, Royal Adelaide Hospital, The University of Sydney, Royal Prince Alfred Hospital, Barwon Health, University Malaya Medical Centre, University of Malaya, Camden and Campbelltown Hospitals, Western Sydney University, Launceston General Hospital, Launceston General Hospital, The Royal Melbourne Hospital, The Alfred Hospital, Westmead Hospital, NSW Health Pathology, Armadale Health Service, Ipswich Hospital, Ipswich Hospital, Metro North Hospital and Health Service, Middlemore Hospital, Lismore Base Hospital, Northern Sydney Local Health District, Charles Sturt University, Université de Montpellier, Royal North Shore Hospital
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
Funders: McGill University, Queen Mary University of London, Children’s Hospital of Wisconsin Research Institute, McGill University Health Centre, Murdoch Children's Research Institute, Australian Government, State Government of Victoria, Medical Research Council, National Health and Medical Research Council
OpenAlex ID: W7147213181