Work

Comparison of survival and establishment of prognostic models for patients with locally advanced squamous cell carcinoma of the hypopharynx at different sites: A retrospective study based on the SEER database

Year: 2026

Type: article

Abstract: ObjectiveTo assess the overall survival (OS) and cancer-specific survival (CSS) in patients with different primary locations of hypopharyngeal squamous cell carcinoma (HSCC) and to develop a predictive model incorporating key clinical and treatment variables (including systemic therapy) to serve as a prognostic reference for patients with locally advanced HSCC.MethodsThis retrospective cohort study extracted data for 1,591 patients with locally advanced HSCC from the Surveillance, Epidemiology, and End Results (SEER) database. X-tile software was used to determine optimal cutoff values for continuous variables. Kaplan-Meier analysis compared survival by primary site. Independent risk factors were identified using stepwise Cox regression, and a nomogram was constructed. Model performance was assessed using the concordance index (C-index), area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).ResultsOS and CSS differed significantly by primary site. Stepwise Cox analysis identified 13 independent prognostic factors. The nomogram showed a C-index of 0.727 in both training and validation sets. The AUCs for 1-, 3-, and 5-year OS were 0.792, 0.791, 0.788 (training) and 0.780, 0.796, 0.789 (validation). Calibration curves indicated good agreement between predicted and observed outcomes. DCA demonstrated superior net benefit over TNM staging alone.ConclusionPrognosis in locally advanced HSCC varies by primary site. The developed nomogram provides moderate prognostic accuracy and may serve as a supplementary tool for risk stratification and clinical discussion, though external validation is warranted.

Source: Science Progress

DOI: 10.1177/00368504261441371

Authors: Han Zhu, Shengteng Shao, Ming Yang, Hua Zhang

Institutions: Qingdao University, Affiliated Hospital of Southwest Medical University, Binzhou Medical University

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,650