Work

Memory of Chirality in Radical Addition–Translocation–Cyclization Cascades

Year: 2026

Type: article

Abstract: ABSTRACT The memory of chirality (MoC) in radical addition‐translocation‐cyclization (RATC) cascades involving chiral nonracemic alkynes has been examined using different hydrofunctionalization procedures. A high level of retention of configuration could be achieved when the rate of cyclization was enhanced due to favorable polar effects. The best system discovered so far was the use of the very electrodeficient pentafluorobenzenesulfonyl moiety. The MoC observed is remarkable if one considers that the system examined possesses no conformational constrain since only σ‐bonds are present in the backbone.

Source: Helvetica Chimica Acta

DOI: 10.1002/hlca.70068

Authors: Christian Simon Gloor, Fabrice Dénès, Valentin Soulard, Philippe Renaud

Institutions: University of Bern, Centre National de la Recherche Scientifique, Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation, Nantes Université

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,030

Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Centre National de la Recherche Scientifique