Work

An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective, Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03223

Authors: Xilin Gu, Pavla Fajtova, Nicholas L. Yan, Aditi Saxena, Fan Fei, Jiyun Zhu, Eric Tse, Arthur Melo, Euna Yoo, Nathan H. Buchwald, Daniel R. Southworth, Matthew Bogyo, Joseph L. Derisi, Jason E. Gestwicki, Anthony J. O’Donoghue, Jason K. Sello

Institutions: University of California San Diego, Harvard University, Chan Zuckerberg Biohub San Francisco, Stanford Medicine, Stanford University, National Cancer Institute, Center for Cancer Research, Brown University, University of California, San Francisco

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: U.S. Department of Defense, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

Awards: Parasite-specific proteasome inhibitors to combat multi-drug resistant malaria, G4863612152, TARGETING THE PLASMODIUM PROTEASOME FOR PROPHYLAXIS AND TREATMENT OF DRUG-RESISTANT MALARIA IN U.S. MILITARY PERSONNEL, Proteasome inhibitors against mucosal protozoan pathogens, New tools to facilitate drug discovery for pathogen proteasomes, Molecular Chaperones and Small Molecules

OpenAlex ID: W7147311856

FWCI: 1.822

Cites: 63

Cited by: 1

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