Work

NDUFA5 deficiency promotes renal inflammation in diabetic nephropathy via mitochondrial ROS signaling

Year: 2026

Type: article

Abstract: . Mechanistically, NDUFA5 attenuated inflammation by inhibiting mitochondrial reactive oxygen species (mtROS) generation. Thus, NDUFA5 protects against DN, at least in part, by preserving mitochondrial integrity and reducing oxidative stress and inflammation, highlighting its potential as a therapeutic target.

Source: iScience

DOI: 10.1016/j.isci.2026.115555

Authors: Guofang Gong, Li Meng, Mengyao Wang, Xiuli Si, Yunzhuo Ren

Institution: Hebei Medical University

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240