Figure 2 from Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions
Year: 2026
Type: other
Abstract: miRNA–gene network analysis identifies miRNAs associated with the antigen presentation gene module downregulated in progressive proliferative subtype PMLs. A, miRNA–gene module network plot shows 321 miRNAs connected to nine gene modules, in which gray circles are miRNAs and colored circles are the gene modules. Edges reflect a miRNA that may have strong suppressive regulatory role over the predicted target genes within the connected gene module based on the two statistical test filters. B, Pearson correlation densities between the module-associated miRNAs connected to each gene module in the miRNA–gene module network and the corresponding gene module GSVA score. C, miRNA–gene network plot of miRNAs connected to the antigen presentation gene module [module 9, purple circle in (A)]. Edges show the significant negative correlations between the miRNAs (gray circles) and the predicted target genes (purple circles). D, Boxplots of residual expression levels of the nine miRNAs specifically connected to module 9 in proliferative subtype biopsies stratified by their outcome status (progressive/persistent samples in dark green and regressive samples in light green). *, P < 0.05, determined by a linear mixed-effects model.
Authors: Boting Ning, Darren J. Chiu, Roxana M. Pfefferkorn, Erin Cullinane, Yohana Kefella, Erin Kane, Valerie Reyes-Ortiz, Gang Liu, Xiaohui Zhang, Hanqiao Liu, Lila Sultan, Emily Green, Myrtha Constant, Avrum E. Spira, Joshua D. Campbell, Mary E. Reid, Xaralabos Varelas, Eric J. Burks, Marc E. Lenburg, Sarah A. Mazzilli, Jennifer E. Beane
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7147399449
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