Supplemental Figure 14 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer
Year: 2026
Type: supplementary-materials
Abstract: Proximity ligation assay of ER-PARP1 co-localization in Y537C cells Representative images of proximity ligation assay ER-PARP1 co-localization puncta in Y537C cells treated for 48 hours with Fulv (100 nM), Olap (5 µM), or Fulv+Olap compared to untreated control (Ctrl) following 5-day estrogen deprivation in charcoal stripped media.
Authors: Sarah K. Herzog, Jessica H. Stevens, Guowei Gu, Sandra L. Grimm, Kloma Cardoza, Autumn G.M. Hawkins, Hangqing Lin, Daniela Ramos, Amanda R. Beyer, David G. Edwards, Derek Dustin, Harry J. Yang, Nicole Liang, Ashfia F. Khan, Tasneem Bawa-Khalfe, Daniel J. McGrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A.W. Fuqua
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7147443392