Work

Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii

Year: 2026

Type: article

Abstract: New dearomatized isoprenylated acylphloroglucinols hyperprzewones A ( 1 ) and B ( 2 ) were isolated and characterized from the dried aerial parts of Hypericum przewalskii . The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to 1 and 2 was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative [4 + 2] cyclization, giving a 17% overall yield. Moreover, the synthetic derivative 8 exhibited moderate inhibition on T-type calcium channels Ca v 3.2. Graphical Abstract

Source: Natural Products and Bioprospecting

DOI: 10.1007/s13659-026-00626-y

Authors: Yong Li, Fei-Fei Xiong, Xiao-Yang Sun, Xing-Ren Li, Dao-Feng Chen, Gang Xu, Yin Nian, Li-Dong Shao

Institutions: Yunnan University of Traditional Chinese Medicine, Kunming Institute of Botany, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Fudan University

Language: English

Topic: Natural Compound Pharmacology Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W7147474069

FWCI: 3.676

Cites: 22

Cited by: 1

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