Work

Figure S11 from In Vivo Auto-tuning of Antibody–Drug Conjugate Delivery to Maximize Efficacy Using High-Avidity, Low-Affinity Antibodies

Year: 2026

Type: other

Abstract: CAPAN-1 T-DXd Efficacy. Individual spider plots of T-DXd efficacy in a low HER2 expression cell line with no treatment control (n = 7), 32 mg/kg HALA antibody only (n = 7), 6.4 mg/kg T-DXd (n = 8), 32 mg/kg Trastuzumab and 6.4 mg/kg T-DXd (5:1) (n = 8), and 32 mg/kg HALA antibody and 6.4 T-DXd (n = 10).

DOI: 10.1158/1535-7163.31923184

Authors: Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A. Desai, Andrew Philippart, Dong Jun Koo, Jennifer J. Linderman, Peter M. Tessier, Greg M. Thurber

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W7147502183

Cites:

Cited by:

Related to: