Work

48P CAF-specific targeting uncovered by patient-derived models synergistically restrains pancreatic tumor progression and chemoresistance

Year: 2026

Type: article

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic stroma dominated by cancer-associated fibroblasts (CAFs), which promote tumor progression, therapeutic resistance, and disease recurrence. Although CAFs represent an attractive therapeutic target, previous CAF-directed strategies have shown limited success due to marked heterogeneity and context-dependent functions. This study aimed to identify novel CAF-specific targets with functional relevance and to assess their potential to enhance chemotherapy efficacy in PDAC.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106153

Authors: Y. Oh, S. Chang

Institutions: University of Ulsan, Asan Medical Center

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910