Work

Dynamic chemical bond-driven sustained release of GDN-PLGA microspheres in injectable composite hydrogels for enhanced wound healing

Year: 2026

Type: article

Abstract: Traditional passive wound dressings struggle to meet the demands of effective wound management. This study developed an intelligent hydrogel composite wound dressing system with microenvironment-responsive characteristics, achieving controlled drug release by constructing a dynamic dual-network structure. Gastrodin-Poly (lactic-co-glycolic acid) (GDN-PLGA) drug-loaded microspheres, with a particle size of 20–80 μm and an encapsulation efficiency of 44.3 ± 2%, are co-loaded into the system, forming an injectable drug-loaded hydrogel (GOA-GDN-PLGA). The results demonstrated that the GOA-GDN-PLGA dual-network injectable hydrogel significantly promotes wound healing. In a rat full-thickness skin defect model, the treatment group achieved a healing rate of 85.4 ± 4% after 14 d, considerably better than the commercial dressing group (51 ± 2%, p <0.01). Histological analysis showed more organized collagen deposition and increased vascular density. These results indicate that the GOA-GDN-PLGA injectable drug-loaded hydrogel facilitates rapid hemostasis and enables controlled drug release, effectively addressing the challenge of multiple administrations of soluble drugs in traditional wound management.

Source: Biomedical Materials

DOI: 10.1088/1748-605x/ae59dc