Work

Mechanical activation of PIEZO1 drives AP-1–dependent PTGS2/PGE2 signaling and corneal inflammation

Year: 2026

Type: article

Abstract: -AP-1-PTGS2/PGE2 axis as a core mechanotransduction pathway driving corneal inflammation. Given the widespread expression of PIEZO1, our results provide mechanistic insight into how abnormal mechanical forces trigger inflammatory responses, highlighting a potential framework for understanding mechano-inflammation across tissues.

Source: iScience

DOI: 10.1016/j.isci.2026.115396