Work

Endocervical gastric‐type AIS : a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Year: 2026

Type: article

Abstract: BACKGROUND: Gastric-type adenocarcinoma in situ (gAIS) is a rare, HPV-independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. AIMS: To report a case of gAIS and its association with pyloric-type gastric metaplasia. MATERIALS AND METHODS: A case of gAIS in a 70-year-old woman with atypical glandular cells (Pap test) and negative HPV molecular testing was evaluated histologically and immunohistochemically. RESULTS: Conization revealed atypical glandular epithelium. The lesion was CK7/CDX2 positive, with mutant-type p53 expression, and negative for CK20, PAX8 and p16. Adjacent pyloric-type gastric metaplasia was identified. DISCUSSION: The association with pyloric-type metaplasia supports a possible metaplastic origin and highlights diagnostic challenges in limited samples. CONCLUSION: This case supports a possible link between gAIS and pyloric-type gastric metaplasia, underscoring the importance of accurate recognition in HPV-independent cervical lesions.

Source: Histopathology

DOI: 10.1111/his.70150

Authors: Michele Paudice, Veronica Parrella, Giulia Scaglione

Institutions: IRCCS Azienda Ospedaliera Metropolitana, University of Genoa, Azienda Sanitaria Locale N. 2 Savonese, Agostino Gemelli University Polyclinic

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,840