Work

Patched controls cell cycle and tissue architecture in Caenorhabditis elegans gonad

Year: 2026

Type: article

Abstract: In this study, we demonstrate how two hedgehog signaling pathway receptors influence germ cell development and reproduction. We identified the roles of Patched receptors in regulating germ cell maintenance, a process that is likely dependent on cholesterol homeostasis. Our findings reveal that dietary cholesterol levels impact Patched-driven germ cell behavior and gonad structure, highlighting the critical role of Patched in germline development.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00486.2025

Authors: Johanna Kate Farley, Madeleine Schwalbe, Fredrik Forsberg, Aqilah Amran, Sandeep Gopal

Institutions: Lund University, Monash University

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid