Work

Early fibrotic gene activation precedes structural remodeling in the heart of cardiac myosin binding protein-C knockout mice

Year: 2026

Type: article

Abstract: The effect of cMyBP-C ablation in the cardiac sarcomere induces cell-signaling changes that precede significant overt fibrosis. These data indicate that early clinical screening may allow for treatment before irreversible, pathological remodeling of the heart takes place.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00226.2025

Authors: Kyrah L. Turner, Taylor G. Christopherson, Bertrand C. W. Tanner

Institution: Washington State University

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, American Heart Association, National Institutes of Health