Figure 6 from Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions
Year: 2026
Type: other
Abstract: Immune and stroma cell composition and epithelial NLRC5 expression is associated with PML progression. A and B, Volcano plots showing the differential composition of progressive/persistent (n = 7) compared with regressive (n = 7) PMLs for (A) cell populations identified in epithelium and (B) cell populations identified in stroma regions. C, Line plot showing the estimated marginal mean of NLRC5 expression with SD in epithelial cells of progressive/persistent (dark green) and regressive (light green) PMLs, respectively, across the three histology regions. Although histology groups were modeled as categorical, the line plot is used to facilitate visualization of trends across histology grades. D, Bubble plot showing the differential expression of NLRC5 between progressive/persistent and regressive PMLs in each epithelial cell population across the three histology contrasts. Color represents the estimate, and dot size represents the log P value computed by a linear mixed-effects model. P values were determined by the sccomp differential composition test (A and B) and linear mixed-effects models (C and D). *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.
Authors: Boting Ning, Darren J. Chiu, Roxana M. Pfefferkorn, Erin Cullinane, Yohana Kefella, Erin Kane, Valerie Reyes-Ortiz, Gang Liu, Xiaohui Zhang, Hanqiao Liu, Lila Sultan, Emily Green, Myrtha Constant, Avrum E. Spira, Joshua D. Campbell, Mary E. Reid, Xaralabos Varelas, Eric J. Burks, Marc E. Lenburg, Sarah A. Mazzilli, Jennifer E. Beane
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7147600848
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