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“The Long Road to a Rare Destination”: Ovarian Serous Carcinoma With Late Thymic Metastasis 25 Years After Diagnosis

Year: 2026

Type: article

Abstract: ABSTRACT We report a rare case of thymic metastasis of ovarian serous carcinoma. A 72‐year‐old woman who had undergone surgery for low‐grade serous carcinoma of the ovary and had been free of disease for 25 years was noted to have rising CA‐125 levels. Further workup revealed a mediastinal mass on imaging. Surgical excision of the mass was performed. Histopathologic and immunohistochemical evaluation confirmed the diagnosis of metastatic ovarian serous carcinoma. Metastatic spread of primary ovarian carcinoma to the thymus is exceedingly rare and reported in only a handful of cases. Here, we report a unique case of metastatic ovarian carcinoma to the thymus presenting 25 years after the initial diagnosis and definitive therapy. This report highlights the importance of considering unusual metastatic sites in the context of ovarian carcinoma.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.72454

Authors: Nicole Fye, Nicholas D'Alonzo, Pauline H. Go, Sanica Bhele

Institution: Penn State Milton S. Hershey Medical Center

Language: English

Topic: Ovarian cancer diagnosis and treatment

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820