Work

Emerging Nanomedicine Strategies for Sepsis: Immunomodulation and Beyond

Year: 2026

Type: article

Abstract: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, initiated by an excessive inflammatory cascade that frequently progresses to immunoparalysis characterized by immune cell dysfunction. In this review, we first provide an overview of the key elements and stages in the onset and progression of sepsis. Subsequently, we discuss the recent advances of biomaterial-based nanomedicine (including organic nanomaterials, inorganic nanomaterials, and natural bio-inspired nanomaterials) in the treatment of sepsis. The elimination of pathogens and the modulation of the immune response within the sepsis microenvironment through the design of diverse biomaterial systems were specifically summarized. Finally, we discuss the challenges and opportunities for biomaterial-based nanomedicine in the treatment of sepsis.

Source: Research

DOI: 10.34133/research.1254

Authors: Kerong Yang, Bingjie Liu, Yunpeng Bai, Shenglong Chen, Chunbo Chen, Junbing Fan

Institutions: Southern Medical University, ShenZhen People’s Hospital, Guangdong Provincial People's Hospital

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500