Work

Janus Kinase Inhibitors in Eosinophilic Granulomatosis With Polyangiitis: An International Case Series

Year: 2026

Type: article

Abstract: First reported by Churg and Strauss in 1951,1 eosinophilic granulomatosis with polyangiitis (EGPA) is a rare small vessel vasculitis histologically characterized by eosinophil-predominant granulomatous inflammation, tissue eosinophilia, and necrotizing vasculitis. Antineutrophil cytoplasmic antibodies (ANCA) are detectable in 30-40% of patients with EGPA,2 typically associated with specific autoantibodies directed against myeloperoxidase (MPO). With heterogenous clinical presentations, no validated diagnostic criteria, and strong overlap with hypereosinophilic syndrome (HES), EGPA can be difficult to diagnose; however, there are a number of classification criteria with established sensitivity and specificity that can be adapted to clinical practice.3

Source: The Journal of Rheumatology

DOI: 10.3899/jrheum.2025-1128

Authors: Paul Anthony John Russo, Jean-Paul Makhzoum, Vincent Cottin, Edoardo Conticini, Giacomo Emmi, Samuel Lawrance Whittle