The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases
Year: 2026
Type: article
Abstract: The heart, as the central organ of the circulatory system, undergoes distinct metabolic transitions from embryonic development through postnatal maturation. A key aspect of this transition is mitochondrial maturation, which is influenced by changes in oxygen levels and metabolic substrates. These changes regulate cardiac structure and function by affecting signaling pathways and transcription factors. In cardiovascular diseases, mitochondria play a crucial role in altering metabolic patterns, contributing to pathological remodeling and worsening disease outcomes. This article explores mitochondrial roles in both cardiac development and disease progression, offering insights into potential therapeutic interventions.
Source: Exploration
DOI: 10.1002/exp.20240414
Authors: Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang
Institutions: Shanghai Medical College of Fudan University, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Obstetrics and Gynecology Hospital of Fudan University, Soochow University, Second Affiliated Hospital of Soochow University, Zhejiang University, Women's Hospital, School of Medicine, Zhejiang University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,500
Award: G2810953708
OpenAlex ID: W7147641229