Supplemental Figure 18 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer
Year: 2026
Type: supplementary-materials
Abstract: Response of ESR1m cells to Olap monotherapy MTT growth assay of Olap monotherapy treatment on ESR1mversus WT cells. Graphs represent mean+standard deviation at indicated concentrations of Olap (concentrations used 0.25-64 µM) with a minimum of 4 replicates per condition. a. MTT for single agent Olap treatment comparing %Viability of F+A and WT cells, with stars indicating statistically significant differences. b. MTT for single agent Olap treatment comparing %Viability of Y537S, Y537C and WT cells, with stars indicating statistically significant differences between WT and Y537S. Statistics comparing %Viability between ESR1mand WT cells at each concentration were calculated utilizing the student’s t-test and are represented by asterisks, *p<0.05, **p<0.01, ***p<0.001, *p<0.0001.
Authors: Sarah K. Herzog, Jessica H. Stevens, Guowei Gu, Sandra L. Grimm, Kloma Cardoza, Autumn G.M. Hawkins, Hangqing Lin, Daniela Ramos, Amanda R. Beyer, David G. Edwards, Derek Dustin, Harry J. Yang, Nicole Liang, Ashfia F. Khan, Tasneem Bawa-Khalfe, Daniel J. McGrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A.W. Fuqua
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7147701678