Figure 6 from Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer
Year: 2026
Type: other
Abstract: Transcriptomic plasticity is a common feature of metastatic cells. A, PDAC tumor cell clonal phylogeny (center), showing the fraction of cells from each site, the fraction of archetypes, and archetype entropy from inside to outside for each clone (leaf in the phylogeny). B, Entropy distributions for three null models and for data in this study (Materials and Methods). Bars indicate the number of clones for each binned entropy value (n = 62 clones for each distribution), curves represent smooth trends, and dashed vertical lines correspond to mean entropy. Observed clones have lower archetype entropy than clones with randomly assigned archetypes, but more than models based on strong archetype bias for metastatic sites, indicating high cellular plasticity. C, PDAC tumor cell phylogeny showing copy-number profiles of each clone, PLASTRO score (Materials and Methods), and archetype composition. The scatterplot indicates that a higher CNA burden is associated with higher plasticity. r, Pearson correlation.
Authors: Alejandro Jiménez-Sánchez, Sitara Persad, Akimasa Hayashi, Shigeaki Umeda, Roshan Sharma, Yubin Xie, Arnav Mehta, Wungki Park, Ignas Masilionis, Tinyi Chu, Feiyang Zhu, Jungeui Hong, Ronan Chaligne, Eileen M. O’Reilly, Linas Mazutis, Tal Nawy, Itsik Pe’er, Christine A. Iacobuzio-Donahue, Dana Pe’er
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7147709472