Work

175P The effect of pancreatic enzyme replacement therapy on the gut microbiome and immune response of patients with pancreatic ductal adenocarcinoma associated pancreatic enzyme insufficiency

Year: 2026

Type: article

Abstract: Pancreatic Enzyme Insufficiency (PEI) affects 70% of patients with Pancreatic Adenocarcinoma (PDAC) and is a negative prognostic factor. Increasing evidence demonstrates that PEI is associated with gut microbiome (GM) dysbiosis. Pancreatic Enzyme Replacement Therapy (PERT) is the mainstay of PEI treatment and has been shown to improve outcomes, but the underlying mechanism is unclear. PERT-associated modulation of the GM and immune response have been suggested as potential mechanisms. The aim of this study was to evaluate how PERT of PDAC associated PEI simultaneously affects gut microbiome composition and peripheral immune profile.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106182

Authors: K. Fung, J. Halle-Smith, T. Iqbal, A. Beggs, P. Moss, K. Roberts

Institutions: University of Birmingham, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910