Work

Advances in the molecular mechanisms and clinical applications of LEMD1 in tumor development and progression (Review)

Year: 2026

Type: article

Abstract: LAP2-emerin-MAN1 (LEM) domain-containing protein 1 (LEMD1), first identified in colorectal cancer in 2004, is a gene that is specifically expressed in the testis. The expression of LEMD1 is minimal in normal somatic cells but high in various types of malignant tumor (such as gastric, prostate, pancreatic and colorectal cancer as well as oral squamous cell carcinoma) due to abnormal promoter demethylation. LEMD1 promotes cell proliferation, invasion and metastasis during tumor progression, making it a potential diagnostic marker and therapeutic target. The present review summarized the research progress of LEMD1 as a cancer-testis antigen in tumor biology. Furthermore, the present review investigated the molecular structure and biological functions of LEMD1, its expression patterns, clinical relevance in various types of tumor, and highlighted current research challenges and future directions.

Source: Molecular and Clinical Oncology

DOI: 10.3892/mco.2026.2948

Authors: Xiao-Bo Wang, Xian-Fei Wang, Sairah Abdul Karim

Institutions: North Sichuan Medical University, Affiliated Hospital of North Sichuan Medical College, Management and Science University

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7147734285

FWCI:

Cites:

Cited by:

Related to: