Human Limb Regeneration: A Mechanistic Convergence Hypothesis
Year: 2026
Type: article
Abstract: White paper on a permissive-signalling framework for possible human limb regeneration studies. This paper argues that the dominant paradigm of instructive signalling — micromanaging each molecular step — is not only unnecessary but potentially counterproductive. We propose a permissive-signalling framework in which a minimal set of environmental conditions is established in the stump, enabling the system's endogenous logic to self-organise. The synthesis integrates twelve biological mechanisms (published between 2013 and 2026) under four permissive pillars — chromatin, metabolic, bioelectric, mechanical — with a thirteenth entry providing an ex vivo validation platform (limb-bud organoids) as a gating step before animal work. We describe a hypothetical convergence protocol that extends the Murugan/Levin 2022 adult Xenopus protocol into a mammalian context, and identify the specific experimental gap — a large-mammal (porcine) bridge experiment — that would translate this framework into a testable clinical pathway. Author: Alejandro García Ruiz. Independent researcher, Toledo, Spain.
Author: Alejandro García Ruiz
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7148385293
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