IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
Year: 2026
Type: article
Abstract: The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We report that in developing zebrafish, enteroendocrine cells produced interleukin-22 (IL-22) in response to microbial signals before lymphocytes populated the gut. In larvae, IL-22 shaped the gut microbiota, increasing Lactobacillaceae abundance and ghrelin expression to promote gut motility. Impaired motility and ghrelin expression were restored in il22 −/− zebrafish by transfer of microbiota from wild-type zebrafish or by introducing only Lactobacillus plantarum . IL-22–deficient mice also had impaired gut motility and reduced ghrelin expression in early life, indicating a conserved function. Thus, before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22.
Source: Science
Authors: Soraya Rabahi, Lucie Maurin, Emiliano Marachlian, Fabian Guendel, Aya Mikdache, Keinis Quintero-Castillo, Vincenzo Di Donato, Jessica Riou-Ramon, Akshai Janardhana Kurup, Yazan Salloum, Gwendoline Gros, Patricia Diabangouaya, Camila Garcia-Baudino, Ignacio Medina-Yáñez, Pascal Hersen, Alvaro Banderas, Jean-Pierre Levraud, Georges Lutfalla, Filippo Del Bene, Carmen G. Feijoo, Gerard Eberl, German Sumbre, Jos Boekhorst, Sylvia Brugman, Pedro P. Hernandez
Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Sciences et Lettres, Sorbonne Université, Génétique et biologie du développement, Institut Curie, École Normale Supérieure - PSL, Institut de Biologie de l'École Normale Supérieure, Institut Pasteur, Université Paris Cité, Universidad Andrés Bello, Institut de la Vision, Physique des Cellules et Cancers, Leibniz-Institute for New Materials, Université Paris-Saclay, Institut des Neurosciences Paris-Saclay, Université de Montpellier, Laboratory of Pathogens and Host Immunity, Wageningen University & Research
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: G1298424190, G1869578429, Deciphering how abnormal intestinal flora determines the vulnerability to chronic pain. Insights from myosin1a knock-out mouse model, G4288197249, G6130892182, G6248994519, G7274551484, Investigating IPO8-dependent immune dysregulation of the GUT: from mechanism to precision medicine
OpenAlex ID: W7148487982